Investigation of the Duration of Low-intensity Focused Ultrasound

Enrolling by invitation · Not applicable

Conditions studied: Development of LIFU for Clinical Purposes

In brief

This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions of the hand.

Key facts

Study ID

NCT05147103

Run by

Virginia Polytechnic Institute and State University

People needed

80

Starts

2022-08-26

Expected to finish

2027-06-01

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Above criteria and must understand and speak English.

You may not qualify if…

• Contraindications to MRI, CT, or TMS
• Claustrophobia
• Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
• Pregnancy
• Active medical disorder or treatment with potential CNS effects
• History of neurologic disorder
• History of head injury resulting in loss of consciousness for >10 minutes
• History of alcohol or drug dependence

Where it is running

• Fralin Biomedical Research Institute — Roanoke, Virginia, United States

Full record on ClinicalTrials.gov

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