Diversity and Inclusion in Research Underpinning Prevention and Therapy Trials

Completed · Not applicable

Conditions studied: Breast Cancer, Liver Cancer, Prostate Cancer

In brief

This proposal brings together multidisciplinary teams from four New York City institutions charged with reducing cancer disparities that affect approximately two million people residing in some of the most diverse and underserved communities in the United States. The intent of this collaborative research is captured by its acronym, DISRUPT: Diversity \& IncluSion in Research Underpinning Prevention \& Therapy Trials. To disrupt the norms that maintain heightened risk and poorer outcomes experienced by BIPOC, the research team propose three integrated and synergistic aims to improve diversity and inclusion in CTs through disruptive approaches at the community (Aim 1), provider, system and patient (Aim 2), and basic and translational scientist levels (Aim 3). All three aims focus on metrics for changing norms reified in institutional policies and established practice that will provide essential evidence to translate and scale these changes to institutions and networks involved in cancer treatment research. In Aim 1, the research team will partner with local organizations to formulate and disseminate new norms regarding cancer care and research and diffuse these new norms throughout the community via community organizations and Health Ambassadors bringing a different vantage point on CTs, raising awareness and increasing demand for access to cancer research. In Aim 2, the research team will create an electronic approach to identify key clinical characteristics of patients and trials and match patients and trials and bring these data to patients and their physicians at the time of key decisions. In Aim 3, the research team will provide and integrate essential experiential training in diversity, social determinants of health and the importance of conducting community-relevant work into basic and translational science training. This DISRUPT proposal provides the foundation to disrupt norms about cancer clinical trials in our communities, delivery systems and scientific research enterprises.

Key facts

Study ID: NCT05146297
Run by: Icahn School of Medicine at Mount Sinai
People needed: 585
Starts: 2023-04-23
Expected to finish: 2026-04-15
Last updated by the study team: 2026-05-19

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

All patients >21 years of age with invasive breast, lung or liver cancer, who face a treatment decision
patients of doctors who have consented to participate
able to give consent and speak either English or Spanish
For provider recruitment, oncologists, and advanced practitioners caring for patients with breast, lung, liver cancer including medical and surgical oncologists, interventional radiologists \& hepatologists will be eligible

You may not qualify if…

Patients who are unable to give consent
unable to understand English or Spanish
lack of invasive breast/liver cancer
those who do not face an imminent treatment decision

Where it is running

Icahn School of Medicine at Mount Sinai — New York, New York, United States
Herbert Irving Comprehensive Cancer Care Center — New York, New York, United States
Albert Einstein College of Medicine — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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