Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences

Completed · Early Phase 1

Conditions studied: Sleep Apnea, Healthy, Vasoconstriction, Vasodilation

In brief

The overall goal of this project is to better understand the effect of intermittent hypoxia (IH) on sympathetic neuronal discharge patterns in humans, as well as mechanisms that mediate persistent sympathoexcitation with IH.

Key facts

Study ID

NCT05146089

Run by

University of Missouri-Columbia

People needed

54

Starts

2016-12-20

Expected to finish

2021-04-12

Last updated by the study team

2021-12-06

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy adult men and women;
• 18-45 years of age;
• BMI <30 kg/m2;
• non-pregnant/non-breastfeeding;
• non-smokers.

You may not qualify if…

• Subjects will be excluded if they are:
• taking any medications known to affect the cardiovascular or autonomic nervous system (e.g. alpha-blockers, beta-blockers, etc);
• Apnea Hypopnea Index >10 events/hr
• Self-reported history of:
• hepatic, renal, pulmonary, cardiovascular, or neurological disease;
• stroke or neurovascular disease;
• bleeding/clotting disorders;
• sleep apnea or other sleep disorders;
• diabetes;
• smoking;
• history of alcoholism or substance abuse;
• hypertension.

Where it is running

• University of Missouri-Columbia — Columbia, Missouri, United States
• Mayo Clinic — Rochester, Missouri, United States

Full record on ClinicalTrials.gov

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