Pain Sensitivity During Puberty
Completed · Not applicable
Conditions studied: Pain
In brief
Aim 1- To examine the differences in pain sensitivity between adolescents at early vs. mid pubertal status Aim 2- To determine the relationships between sex hormone levels and pain sensitivity Exploratory Aim 1- To determine the effect of pubertal maturation on pain sensitivity Exploratory Aim 2- To identify parameters related to who will develop chronic pain during puberty Hypothesis 1- Adolescents in early pubertal status will have higher pain ratings and lower pain modulation capabilities compared to adolescents in mid puberal status. Hypothesis 2- Pain sensitivity will be associated with sex hormone levels. Exploratory Hypothesis 1- As adolescents mature, they will have a decrease in pain sensitivity to experimental pain which will be related to changes in sex hormone levels. Exploratory hypothesis 2- Female adolescents with greater pain sensitivity, lower testosterone levels and with a family history of pain would be at a higher risk to develop chronic pain
Key facts
- Study ID
- NCT05145595
- Run by
- Washington University School of Medicine
- People needed
- 36
- Starts
- 2022-09-20
- Expected to finish
- 2024-07-17
- Last updated by the study team
- 2026-01-09
Who can join
Age: 9 and older, up to 16. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy males and females
- 9-16 years old
- English speakers
You may not qualify if…
- Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
- Pregnancy
- Chronic Pain or frequent headaches (>5 headache /month)
- Psychiatric or neurological disorders
- Lack of sensation in the testable limb
- Disorders associated with pubertal maturation or usage of contraceptive pills that affect sex hormone levels
- Regular use of pain medications (e.g., opioids, antidepressants).
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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