Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Opioid Use Disorder, Back Pain, Stress

In brief

The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.

Key facts

Study ID

NCT05142267

Run by

Vanderbilt University Medical Center

People needed

120

Starts

2022-03-02

Expected to finish

2026-07-31

Last updated by the study team

2025-10-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intact cognitive status and ability to provide informed consent
• Ability to read and write in English sufficiently to understand and complete study questionnaires (which are only validated in English)
• Age 18 or older And
• Presence of persistent daily low back pain of at least three months duration and of at least a 3/10 in average intensity

You may not qualify if…

• History of renal or hepatic dysfunction
• Reports of current or past alcohol or substance abuse or treatment for such condition
• A reported history of PTSD, psychotic, or bipolar disorders
• Chronic pain due to malignancy (e.g., cancer) or autoimmune disorders (e.g., rheumatoid arthritis, lupus)
• Reports of recent benzodiazepine use (confirmed via rapid urine screening prior to each lab session)
• Any medical conditions (e.g., significant cardiovascular disease) that the study physician feels would contraindicate participation in the lab stressors
• Reported daily opiate use within the past 6 months, or use of any opioid analgesic medications within 3 days of study participation (confirmed through rapid urine screening prior to each lab session)
• Pregnancy (females only, to avoid fetal drug exposure - pregnancy tests conducted prior to each lab session to confirm eligibility)
• Prior allergic reaction/intolerance to oxycodone or its analogs

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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