Prediction of Neoadjuvant Chemotherapy Efficacy in Locally Advanced Gastric Cancer

Recruiting now · Not applicable

Conditions studied: Gastric Cancer

In brief

This study intends to explore the value of 68Ga-FAPI-04 and 18F-FDG PET/CT in the evaluation of treatment response to neoadjuvant chemotherapy(NAC) for patients with locally advanced gastric cancer(LAGC).

Key facts

Study ID

NCT05140746

Run by

Ruijin Hospital

People needed

40

Starts

2020-09-10

Expected to finish

2027-09-10

Last updated by the study team

2024-01-09

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18-75 years.
• Histologically confirmed gastric adenocarcinoma through gastroscopy.
• Resectable gastric cancer.
• ECOG performance status 0-1.
• White blood count >4x109/L, Absolute neutrophil count (ANC) >2x109/L, Hemoglobin (Hb)>90g/L, Platelets >100x109/L.
• Ejection Fraction>50%.
• Serum bilirubin <1.5x ULN; ALT and AST <1.5x ULN.
• Serum creatinine ≤1.5x ULN, or GFR> 60ml/min.
• Agreement to participate in this study with informed consent form.
• Willingness and ability to comply with the protocol for the duration of the study.
• No children bearing petential in the next six months before enrollment.

You may not qualify if…

• With second primary malignant diseases in past five years, exceptions include basal cell and squamous cell carcinoma of the skin that have been cured.
• Known hypersensitivity reaction to chemotherapy drugs or with contraindications.
• With severe disease or other unsuitable conditions determined by investigators. Inadequate organ function.
• With uncontrollable diabetic or fasting blood glucose level ≥11 mmol/L on the test-day.
• With severe mental symptoms, unconscious or unable to complete the examination.
• Pregnancy or possibly pregnant woman, breastfeeding woman.
• Lack of compliance.

Where it is running

• Shanghai Ruijin Hospital — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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