OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK-LRx) in Participants With Hereditary Angioedema (HAE)
Completed · Phase 3 · Has a placebo group
Conditions studied: Hereditary Angioedema
In brief
The purpose of this study was to evaluate the safety and efficacy of donidalorsen in participants with HAE and effect of donidalorsen on the quality and pattern of HAE attacks and their impact on quality of life (QoL).
Key facts
- Study ID
- NCT05139810
- Run by
- Ionis Pharmaceuticals, Inc.
- People needed
- 91
- Starts
- 2021-12-03
- Expected to finish
- 2023-11-09
- Last updated by the study team
- 2025-03-06
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Ionis Investigative Site — Odense, Denmark
- Ionis Investigative Site — La Tronche, France
- Ionis Investigative Site — Marseille, France
- Ionis Investigative Site — Paris, France
- Ionis Investigative Site — Scottsdale, Arizona, United States
- Ionis Investigative Site — San Diego, California, United States
- Ionis Investigative Site — Santa Monica, California, United States
- Ionis Investigative Site — Walnut Creek, California, United States
- Ionis Investigative Site — Colorado Springs, Colorado, United States
- Ionis Investigative Site — Tampa, Florida, United States
- Ionis Investigative Site — Kansas City, Kansas, United States
- Ionis Investigative Site — Boston, Massachusetts, United States
- Ionis Investigative Site — Ann Arbor, Michigan, United States
- Ionis Investigative Site — St Louis, Missouri, United States
- Ionis Investigative Site — Columbus, Ohio, United States
- Ionis Investigative Site — Toledo, Ohio, United States
- Ionis Investigative Site — Hershey, Pennsylvania, United States
- Ionis Investigative Site — Dallas, Texas, United States
- Ionis Investigative Site — Murray, Utah, United States
- Ionis Investigative Site — Brussels, Belgium
- Ionis Investigative Site — Brussels, Belgium
- Ionis Investigative Site — Edegem, Belgium
- Ionis Investigative Site — Sofia, Bulgaria
- Ionis Investigative Site — Sofia, Bulgaria
- Ionis Investigative Site — Edmonton, Canada
Full record on ClinicalTrials.gov
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