BeAT1D: Benign Autoimmunity and Type 1 Diabetes

Recruiting now

Conditions studied: Type 1 Diabetes

In brief

National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.

Key facts

Study ID

NCT05139784

Run by

Institut National de la Santé Et de la Recherche Médicale, France

People needed

1160

Starts

2022-10-24

Expected to finish

2030-04-01

Last updated by the study team

2026-05-22

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Type 1 diabetes: type 1 diabetes, as defined by hyperglycemia and long-term insulin therapy started within 6 months from clinical onset; and/or the presence of at least one anti-islet auto-antibody.
• Other forms of diabetes or autoimmune endocrinopathy: other forms of diabetes (e.g. type 2, ketosis-prone, familial, secondary, immunotherapy-induced diabetes); and/or other autoimmune endocrinopathies, isolated or multiple.
• No diabetes: absence of diabetes or impaired glucose tolerance; absence of tumor, infectious or immune pathologies, or other conditions related to autoimmune or metabolic alterations that may bias the variables under study.
• Lymphadenectomy planned in the frame of an abdominal surgery: pancreatic lymphadenectomy planned at the occasion of an abdominal surgery for the treatment of an underlying condition.

You may not qualify if…

• For all participants: ongoing pregnancy; known HIV/HCV infection; absence of social security coverage; placement under judicial protection; absence of signature of the informed study consent.

Where it is running

• APHP Hôpital Cochin - Service de Diabétologie et Immunologie Clinique — Paris, Île-de-France Region, France (enrolling)
• APHP Hôpital J. Verdier — Bondy, Île-de-France Region, France
• APHP Hôpital L. Mourier — Colombes, Île-de-France Region, France
• Hôpital Sud Francilien — Corbeil-Essonnes, Île-de-France Region, France
• Hôpital Mignot - Service de Pédiatrie — Le Chesnay, Île-de-France Region, France
• Hôpital Mignot - Services de Diabétologie/Endocrinologie Adultes — Le Chesnay, Île-de-France Region, France
• APHP Hôpital Kremlin-Bicêtre — Le Kremlin-Bicêtre, Île-de-France Region, France
• APHP Hôpital Lariboisière — Paris, Île-de-France Region, France
• APHP Hôpital Saint Antoine — Paris, Île-de-France Region, France
• APHP Hôpital Pitié-Salpêtrière - Service de Chirurgie — Paris, Île-de-France Region, France
• Hôpital Pitié-Salpêtrière - Service de Diabétologie — Paris, Île-de-France Region, France
• APHP Hôpital Cochin - Service de Chirurgie — Paris, Île-de-France Region, France
• APHP Hôpital Européen G. Pompidou — Paris, Île-de-France Region, France
• APHP Hôpital Bichat — Paris, Île-de-France Region, France
• APHP Hôpital R. Debré — Paris, Île-de-France Region, France
• APHP Hôpital Avicenne — Bobigny, Île-de-France Region, France
• Hôpital René Dubos — Pontoise, Île-de-France Region, France

Full record on ClinicalTrials.gov

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