Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
Recruiting now
Conditions studied: Amyotrophic Lateral Sclerosis, Movement Disorders, Degenerative Disorder, Motor Neuron Disease
In brief
The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information that are made available to the research community. To accomplish these goals, we will enroll 800 Amyotrophic Lateral Sclerosis (ALS) patients and 200 healthy controls from sites globally, over a 5 year time frame. Additionally, speech and motor function and spirometry measures will be collected bi-weekly in a subset of participants. ALS participants will be asked to come to the clinic for 5 study visits approximately every 4 months. Healthy participants will be coming for 2 study visits with a 12-month interval between visits. These samples and clinical information will be stored in a de-identified manner and made available for investigators to use in future research studies.
Key facts
- Study ID
- NCT05137665
- Run by
- Target ALS Foundation, Inc.
- People needed
- 1000
- Starts
- 2021-06-01
- Expected to finish
- 2031-12-31
- Last updated by the study team
- 2025-11-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- Barrow Neurological Institute — Phoenix, Arizona, United States (enrolling)
- University of California San Diego — San Diego, California, United States (enrolling)
- Georgetown University — Georgetown, District of Columbia, United States (enrolling)
- Mayo Clinic — Jacksonville, Florida, United States (enrolling)
- Northwestern University — Chicago, Illinois, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- Washington University — St Louis, Missouri, United States (enrolling)
- Columbia University — New York, New York, United States (enrolling)
- Baylor College of Medicine — Houston, Texas, United States (enrolling)
- University of Washington — Seattle, Washington, United States (enrolling)
- Instituto Roosevelt — Bogotá, Colombia (enrolling)
- CHALS-CCT UPR MScience — San Juan, Puerto Rico (enrolling)
Full record on ClinicalTrials.gov
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