Investigation of Low-intensity Focused Ultrasound Parameters

Completed · Not applicable

Conditions studied: Development of LIFU for Clinical Purposes

In brief

This project examines the effects of different brain stimulation settings on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, an fMRI and CT. These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions on the hand.

Key facts

Study ID

NCT05134233

Run by

Virginia Polytechnic Institute and State University

People needed

23

Starts

2022-01-14

Expected to finish

2024-03-11

Last updated by the study team

2025-01-23

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Above criteria and must understand and speak English.

You may not qualify if…

• Contraindications to MRI, CT, or TMS
• Claustrophobia
• Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
• Pregnancy
• Active medical disorder or treatment with potential CNS effects
• History of neurologic disorder
• History of head injury resulting in loss of consciousness for >10 minutes
• History of alcohol or drug dependence
• Failure to provide a social security number or tax ID number. This is required for tax purposes or payment cannot be processed.

Where it is running

• Fralin Biomedical Research Institute — Roanoke, Virginia, United States

Full record on ClinicalTrials.gov

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