Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk

Recruiting now · Not applicable

Conditions studied: Psychosis, Prodromal Schizophrenia, Prodromal Symptoms

In brief

This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. This remotely-delivered intervention combining targeted cognitive training exercises and group support was developed to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.

Key facts

Study ID

NCT05131035

Run by

Northwell Health

People needed

54

Starts

2021-10-28

Expected to finish

2026-05-31

Last updated by the study team

2025-11-24

Who can join

Age: 14 and older, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet Clinical High Risk (CHR) criteria on the Structured Interview for Psychosis Risk Syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level
• A score representing 0.5 SD below the mean on Animal Naming, Trails A or BACS: Symbol Coding from the MATRICS Consensus Cognitive Battery (MCCB).

You may not qualify if…

• Any DSM 5 Schizophrenia-Spectrum diagnosis
• Non-English speaking
• Past or current history of a clinically significant central nervous system disorder (e.g., seizure disorder)
• Estimated IQ<70
• Significant head injury
• Significant substance abuse
• Significant visual or auditory impairment.

Where it is running

• Northwell Health- The Zucker Hillside Hospital — Glen Oaks, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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