PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Methamphetamine-dependence, Postpartum Abstinence

In brief

The PRevention Of Methamphetamine Use among Postpartum Women Trial (PROMPT) is randomized controlled trial of postpartum individuals with methamphetamine use disorder to 12 weeks of 200 mg oral micronized progesterone twice daily or placebo. The aims of this study are to assess the feasibility, safety and preliminary efficacy of micronized progesterone for the prevention of return to methamphetamine use. A secondary aim is to assess participant's salivary levels of allopregnanolone with methamphetamine cravings. This study has the potential to provide effective interventions to prevent methamphetamine use among postpartum women.

Key facts

Study ID

NCT05128071

Run by

University of Utah

People needed

34

Starts

2022-02-04

Expected to finish

2024-05-30

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Meeting criteria for substance use disorder of methamphetamine in the six months prior to conception or during pregnancy
• No active methamphetamine use at time of enrollment or within past 4 weeks prior to enrollment by self-report or urine toxicology.
• If diagnosis of active opioid use disorder (OUD) and no use at time of enrollment or within past 4 weeks prior to enrollment by self-report or urine toxicology and on stable dose of medication for OUD (methadone, buprenorphine, naltrexone) for two weeks prior to enrollment in order to allow for postpartum dose adjustments.
• Intrauterine device or barrier method for contraception during the study period
• End of pregnancy within past 12 weeks
• Residing within 100 miles of study site
• Stable on allowable psychiatric medications including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and mood stabilizers for four weeks prior to enrollment

You may not qualify if…

• Major medical illness in which progesterone may be contraindicated (significant liver disease, history of thrombophlebitis, stroke, heart disease, suspected or known malignancy, deep vein thrombosis, pulmonary embolus, clotting or bleeding disorders)
• Any of the following laboratory abnormalities (within 2 weeks of screening and enrollment)
• Active hepatic dysfunction
• Anemia defined as hemoglobin less than 8 g/dL indicating anemia
• Renal impairment defined as creatinine greater than 2.0 mg/dL
• Hypothyroidism defined as TSH greater than 5 mIU/L
• Abnormal vital signs at baseline visit
• Allergy to micronized progesterone or ingredients in placebo including peanut oil, gelatin or cellulose
• Self-reported progestin-containing oral or depot containing contraceptives intolerance.
• Do not speak English or Spanish
• Taking potent inhibitors of CY P450 3A4 including clarithromycin, erythromycin, diltiazem, itraconazole, ketoconazole, ritonavir, verapamil and goldenseal.
• Severe depressive symptoms
• Active suicidality
• Current or past history of psychosis, suicidal attempts or psychiatric hospitalizations
• Current or pending incarceration
• Active alcohol use disorder within past six months
• Use of the following concomitant drugs, supplements and over-the-counter medications in the two week prior to enrollment: stimulants, barbiturates, benzodiazepines, non-benzodiazepine hypnotics, orexin antagonists, first generation anti-histamine, herbal sedatives, methaqualone and analogues, skeletal muscle relaxants, opioids (other than methadone or buprenorphine), anti-psychotic medications, certain anti-depressants or other medication with significant sedative properties as evaluated by the PI and/or study clinician.
• Progestin containing medications including oral hormonal contraceptive methods

Where it is running

• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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