A Target Occupancy Study With Ritlecitinib.
Completed · Phase 1
Conditions studied: Healthy
In brief
This is a phase 1, open label, two-arm study to assess target occupancy and functional inhibition of JAK3 and TEC kinases by Ritlecitinib in healthy adult participants
Key facts
- Study ID
- NCT05128058
- Run by
- Pfizer
- People needed
- 16
- Starts
- 2021-10-22
- Expected to finish
- 2022-01-14
- Last updated by the study team
- 2023-11-13
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants are eligible to be included in the study only if all the following criteria apply:
- Participants who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures.
- Male and female participants who are overtly healthy as determined by medical evaluation including medical history, physical examination including BP and pulse rate measurement, 12-lead ECG, or clinical and laboratory tests.
- BMI of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lb).
You may not qualify if…
- Participants are excluded from the study if any of the following criteria apply:
- Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing).
- Infection with HIV, hepatitis B or hepatitis C viruses
- Have evidence of untreated or inadequately treated active or latent Mycobacterium TB infection
- Known active or history of recurrent bacterial, viral, fungal, mycobacterial or other infections.
- Have received only one of the 2 required doses of COVID-19 vaccine.
- Participants have a known present or a history of malignancy other than a successfully treated or excised non metastatic basal cell or squamous cell cancer of the skin or cervical carcinoma in situ.
Where it is running
- Pfizer Clinical Research Unit - New Haven — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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