Impact of Obesity on Clinical Outcomes in Patients Receiving Acyclovir for HSV Encephalitis"
Completed
Conditions studied: HSV Encephalitis
In brief
Multicenter retrospective chart review of patients admitted to any of the six study centers (SSM Health - St. Clare, St. Mary's, Saint Louis University Hospital, St. Anthony's, St. Mary's Madison, Rush University Medical Center, or Methodist Dallas Medical Center) between January 1, 2013 and December 31, 2019 will be conducted. All study centers utilize Epic ® electronic health record (Verona, Wisconsin; www.epic.com) for which all data will be extracted from. Each study center will obtain individual IRB approval prior to data collection. SSM - St. Clare will serve as the lead center for the study with all other centers sending collected and de-identified data to this central site for analysis.
Key facts
- Study ID
- NCT05127395
- Run by
- Methodist Health System
- People needed
- 50
- Starts
- 2021-03-09
- Expected to finish
- 2023-04-12
- Last updated by the study team
- 2026-03-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients Admitted to a SSM Health - St. Clare (STL), St. Mary's (STL), Saint Louis University Hospital (STL), St. Anthony's (OKC), St. Mary's Madison (WIS), Rush University Medical Center (RUMC), or Methodist Dallas Medical Center
- > 18 years old
- Positive cerebrospinal fluid (CSF) PCR for HSV-1 or HSV-2
- BMI > 30 kg/m2
- Received guideline-approved, weight-based doses of IV acyclovir for HSV encephalitis for at least 72 hours during the index admission
- Received appropriately renal dose-adjusted doses of IV acyclovir per package insert recommendations
You may not qualify if…
- More than one dosing weight strategy utilized for > 24 hours for IV acyclovir dosing during the index admission
- Patients transferred to the hospital already on IV acyclovir for HSV encephalitis
- ESRD on admission
- Concomitant pathogen causing meningitis or encephalitis
- Oral acyclovir used for treatment
Where it is running
- Methodist Charlton Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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