Resilience and Brain Health of Older Adults (MEDEX-2)

Enrolling by invitation · Not applicable

Conditions studied: Age-related Cognitive Decline

In brief

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Key facts

Study ID

NCT05124132

Run by

Washington University School of Medicine

People needed

468

Starts

2019-04-16

Expected to finish

2027-08-31

Last updated by the study team

2026-06-12

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participated in the parent study, Protocol ID #201410093

You may not qualify if…

• Inability to safely continue classes or complete assessments, as per PI discretion

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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