Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors

Running, not enrolling · Not applicable

Conditions studied: Sarcoma, Melanoma

In brief

This is a single arm, phase I study, evaluating the feasibility, toxicity, and degree of tumor response after novel proton pencil beam scanning (PBS GRID) treatment in patients with bulky tumors that are difficult to manage.

Key facts

Study ID

NCT05121545

Run by

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

People needed

11

Starts

2022-04-06

Expected to finish

2026-12-01

Last updated by the study team

2026-01-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18
• Histologically or cytologically confirmed invasive cancer
• Bulky tumor > 7 cm, determined clinically and/or radiographically, at the time of evaluation prior to enrollment
• Treated indicated for palliative intent
• Eastern Cooperative Oncology Group (ECOG) performance status < 2
• Anticipated treatment deemed safe on pre-review by PI
• For patients with prior Radiation Therapy (RT): Dicoms must be available for dose fusion if overlap anticipated with GRID
• Willing and able to provide informed consent
• Discussion with medical oncology or surgical specialty

You may not qualify if…

• Age < 18
• ECOG performance status 3-4
• Planned for definitive, curative management
• For patients with prior RT that overlaps with Pro-GRID: Dicoms not available Pregnant women
• Tumor encasing critical structure, as defined by the treating MD.

Where it is running

• Sibley Memorial Hospital — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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