A Study of the Safety, Tolerability and Effectiveness of EZM0414 (IPN60210) Investigative Product in Participants With Relapsed/Refractory Multiple Myeloma and Relapsed/Refractory Diffuse Large B Cell Lymphoma

Stopped early · Phase 1

Conditions studied: Multiple Myeloma, Refractory, Diffuse Large B-Cell Lymphoma, Diffuse Large B Cell Lymphoma Refractory, Multiple Myeloma in Relapse

In brief

This study will include participants with relapsed/refractory (R/R) Multiple Myeloma (MM). MM is a type of cancer of the blood. This study will also include participants with relapsed/refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL). DLBCL is also a type of cancer of the blood. They are referred to as 'relapsed' when the disease has come back after treatment and 'refractory' when treatment no longer works. The study has 2 main parts, called phase 1 and phase 1b. The main objective of both parts will be to evaluate the safety and tolerability of the study drug, called EZM0414. The main objective of phase 1b will also be to determine the effectiveness of EZM0414. During phase 1 six dose levels will be tested to obtain the most tolerated dose. Participants will receive study drug at the assigned dose level every 28 days. During phase 1b participants will receive study drug at the maximum tolerated dose in 28-day cycles.

Key facts

Study ID

NCT05121103

Run by

Epizyme, Inc.

People needed

13

Starts

2022-05-31

Expected to finish

2024-04-30

Last updated by the study team

2025-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Voluntarily provide signed informed consent after review of verbal and written material about the trial and agree to abide with protocol requirements. All study related activities must be carried out after written consent is obtained.
• Subjects must be ≥18 years of age at the time of signing the ICF (Informed Consent Form).
• Subjects must have an Eastern Cooperative Oncology Group (ECOG) status of 0 - 2.
• For MM, subjects must have measurable disease by IMWG (International Myeloma Working Group) 2016 criteria
• For DLBCL, subjects must have measurable disease by Lugano criteria
• Females must not be breastfeeding or pregnant at screening
• Females of childbearing potential must not have had unprotected sexual intercourse while participating in this study
• Male subjects must either practice complete abstinence or agree to use a latex or synthetic condom, even with a successful vasectomy, during study treatment and for 30 days after the final dose of study treatment

You may not qualify if…

• Subjects with plasma cell leukemia defined as a plasma cell count >2000/mm3.
• Subjects with Waldenstrom's macroglobulinemia or smoldering MM.
• Subjects who had prior treatment with SETD2 or NSD2 inhibitor.
• Subjects with active acute or chronic systemic infection requiring systemic treatment, including COVID-19.
• Has cardiovascular impairment
• Prolongation of corrected QT interval using Fridericia's formula (QTcF) to > 480 msec or history of long QT syndrome.
• Known left ventricular ejection fraction (LVEF) < 50% by either echocardiogram (ECHO) or multigated acquisition (MUGA).
• Prior major surgery within 4 weeks of treatment start.
• Known hypersensitivity to components of the investigational product.
• Subjects who have received treatment with any unapproved drug product within 4 weeks prior to screening.
• Current participation in any other interventional clinical study except for follow up.
• Subjects with a history of or active malignancy other than disease under study
• Underlying medical/social conditions that in PI opinion will place the subject in significant risk and affect the interpretation of toxicity and adverse events assessments.
• Inability to take oral medication or known gastrointestinal (GI) disease, GI procedure or medical condition that could interfere with the oral absorption or tolerance of the study drug

Where it is running

• City of Hope — Duarte, California, United States
• Astera Cancer Care — East Brunswick, New Jersey, United States
• Weill Cornell Medicine — New York, New York, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• Baylor University Medical Center (Texas Oncology) — Dallas, Texas, United States
• MD Anderson Cancer Center — Houston, Texas, United States
• NEXT Virginia — Fairfax, Virginia, United States

Full record on ClinicalTrials.gov

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