Pathogen-microbiome Interaction During Helicobacter Pylori Infection

Recruiting now

Conditions studied: Helicobacter Pylori Infection

In brief

Helicobacter pylori affects the gut microbiome in ways that are only partially understood. In which patients H. pylori causes severe disease and in whom it merely colonizes, possibly even with beneficial effects, is not understood. The investigators are pursuing the hypothesis that changes in the gut microbiome that can be easily measured in stool have such predictive value.

Key facts

Study ID

NCT05121025

Run by

University Hospital Freiburg

People needed

180

Starts

2022-03-11

Expected to finish

2025-12-30

Last updated by the study team

2024-12-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients: -
• Male and female patients aged ≥ 18 years.
• Specimens from patients undergoing tissue sampling, stool, and blood to rule out Helicobacter pylori infection
• Written informed consent from patients.
• Volunteer subjects: -
• Male and female (non-pregnant) volunteers between the ages of 18-65 years.
• Written informed consent from volunteers.
• No acute medical conditions
• No regular medication use, and no antibiotic use in the last 4 weeks.

You may not qualify if…

• Patients: -
• Minor patients
• Patients not capable of giving consent
• Samples without sufficient residual material after standard diagnostic procedures
• Samples from patients who have not given consent for testing
• Volunteer subjects: -
• Subjects not capable of giving consent
• Subjects with acute illnesses
• Subjects older than 65 or younger than 18 years of age.
• Pregnant women

Where it is running

• Institute for Microbiology and Hygiene — Freiburg im Breisgau, Baden-Wurttemberg, Germany (enrolling)

Full record on ClinicalTrials.gov

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