Modulation of Frontoparietal Dynamics Underlying Adolescent Working Memory Deficits
Completed · Not applicable
Conditions studied: ADHD
In brief
The purpose of this study is to test whether a single session of brain stimulation (called repetitive transcranial magnetic stimulation \[rTMS\]) can improve the brain activity underlying 'working memory.' Working memory is the ability to hold information 'in mind' to complete daily activities. This study involves teenagers with ADHD as well as healthy young adults. It is funded by The COBRE Center for Neuromodulation (CCN) at Butler Hospital (Pilot Project)
Key facts
- Study ID
- NCT05119660
- Run by
- Bradley Hospital
- People needed
- 20
- Starts
- 2021-10-01
- Expected to finish
- 2025-03-30
- Last updated by the study team
- 2026-07-09
Who can join
Age: 13 and older, up to 25. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ability to provide assent and have parent provide parental permission
- English fluency of the participant and the legal guardian/parent
- 13-18 years
- Parent rating on BRIEF-2 Working Memory: Greater than 1.0 SD above normative mean.
- IQ > 80
- Clinical diagnosis of attention deficit hyperactivity disorder (ADHD): predominantly inattentive type, predominantly hyperactive/impulsive type, combined type, or unspecified type. Diagnostic criteria will be confirmed with NICHQ Vanderbilt Assessment Scales-Parent.
- Healthy Control Arm: We will target a sample of healthy, young adults. Inclusion Criteria
- Ability to provide consent
- English fluency of the participant
- 18-25 years
- Never diagnosed or meets current criteria for a psychiatric disorder, as measured by self-report of prior diagnoses and formal completion of the diagnostic interview.
- Exclusion Criteria: For patient and healthy control participants
- Participants will be screened to exclude individuals with neurological or medical conditions that might confound the results, as well as to exclude participants in whom MRI or TMS might result in increased risk of side effects or complications. Common contraindications include metallic hardware in the body, cardiac pacemaker, patients with an implanted medication pumps or an intracardiac line, or prescription of medications known to lower seizure threshold. These account for the majority of the exclusion criteria listed below:
- Intracranial pathology from a known genetic disorder (e.g., NF1, tuberous sclerosis) or from acquired neurologic disease (e.g. stroke, tumor), cerebral palsy, history of severe head injury, or significant dysmorphology
- History of fainting spells of unknown or undetermined etiology that might constitute seizures
- History of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy
- Any progressive (e.g., neurodegenerative) neurological disorder
- Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
- Contraindicated metal implants in the head, brain or spinal cord (excluding dental implants, braces or fillings)
- Non-removable makeup or piercings
- Pacemaker
- Implanted medication pump
- Vagal nerve stimulator
- Deep brain stimulator
- TENS unit (unless removed completely for the study)
Where it is running
- E. P. Bradley Hospital — East Providence, Rhode Island, United States
Full record on ClinicalTrials.gov
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