Influence of Graded Hypercapnia on Endurance Exercise Performance

Completed · Not applicable

Conditions studied: Hypercapnia

In brief

The aim of this randomized, single-blind, placebo-controlled crossover trial is to determine the effects of graded hypercapnia (0, 2, and 4% inspired CO2) on endurance performance. Twelve healthy and fit young adults (men and women) will complete this study. Participants will perform experimental trials on 3 separate days (one each breathing 0%, 2%, and 4% inspired CO2-all with normal 21% oxygen). During each trial, they will perform 10 minutes of submaximal treadmill walking exercise and then complete a self-paced 2-mile treadmill run time-trial.

Key facts

Study ID

NCT05116397

Run by

United States Army Research Institute of Environmental Medicine

People needed

15

Starts

2021-09-10

Expected to finish

2022-04-14

Last updated by the study team

2022-05-31

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female, age 18-45
• In good health as determined by medical screening
• Passed his/her most recent Army Combat Fitness Test (ACFT) (Military Volunteers Only) or performs aerobic exercise at least 2 times per week and able to complete two mile run in ≤ 21 minutes (Civilian Volunteers)
• Willing to not participate in any exercise or drink alcoholic beverages for 24 hours before each study visit.
• Willing to not take part in any strenuous exercise in the 36 hours before each visit.
• Willing not to drink caffeine or eat food until after testing on familiarization and performance testing visits (visits 2-6).
• Willing to maintain a similar dietary pattern in the 2 days before each familiarization and performance visits.
• Have supervisor approval if permanent party military or a federal employee at U.S. Army Natick Soldier System Center
• Able to speak and read English fluently

You may not qualify if…

• Females who are pregnant or planning to become pregnant during the study
• Taking dietary supplements, prescriptions, or over the counter medication, other than a contraceptive (unless approved by medical staff \& PI)
• Musculoskeletal injuries that compromise ability to run on a treadmill
• Abnormal blood count, presence of abnormal blood chemicals (hemoglobin S or sickle cell traits)
• Smokers or tobacco/nicotine users (unless have quit > 1 month prior)
• Any history of asthma
• Current or recent respiratory tract or sinus infections (< 1 month prior)
• Allergy to skin adhesive
• Any history of migraine or recurrent headaches
• Any history of panic disorder
• Blood donation in the previous 8 weeks
• Positive Covid-19 test within the last month

Where it is running

• USARIEM — Natick, Massachusetts, United States

Full record on ClinicalTrials.gov

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