Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI

Withdrawn before enrolling · Not applicable

Conditions studied: Acute Kidney Injury, Acute Kidney Injury Due to Sepsis, Neonatal Sepsis

In brief

This study will follow patients admitted to the PICU with sepsis, NICU with sepsis or after abdominal surgery, or CICU who are identified as being at risk for developing acute kidney injury. The investigators will use risk-stratification, biomarker testing, and a functional assessment to predict children and neonates who will become fluid overloaded and develop severe acute kidney injury.

Key facts

Study ID

NCT05114057

Run by

Children's Hospital Medical Center, Cincinnati

People needed

0

Starts

2026-03-01

Expected to finish

2029-07-01

Last updated by the study team

2026-03-24

Who can join

Age: any, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to the Pediatric Intensive Care Unit (PICU), Cardiac Intensive Care Unit (CICU), or Neonatal Intensive Care Unit (NICU) at participating institution

You may not qualify if…

• Baseline Chronic Kidney Disease (CKD) Stage IV or V (estimated GFR <60 mL/min/1.736m2)
• History of kidney transplant within the previous 90 days
• Ongoing AKI or Acute Kidney Disease (AKD) at ICU admission requiring renal replacement therapy initiated prior to ICU admission
• Acute DNR order or clinical team is not committed to escalating medical care
• Anticipated to require intensive care for less than 48 hours

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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