Study of ATH434 in Participants with Multiple System Atrophy

Completed · Phase 2 · Has a placebo group

Conditions studied: Multiple System Atrophy

In brief

This study will assess the safety and efficacy of ATH434 in participants with Multiple System Atrophy

Key facts

Study ID

NCT05109091

Run by

Alterity Therapeutics

People needed

77

Starts

2022-07-01

Expected to finish

2024-11-28

Last updated by the study team

2024-12-13

Who can join

Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant has clinical features of parkinsonism.
• Participant has evidence of orthostatic hypotension and/or bladder dysfunction.
• Participant has ataxia and/or pyramidal signs on neurological examination.
• Participant is ambulatory.
• Participant has biomarker evidence of MSA in biologic fluid and on MRI.

You may not qualify if…

• Participant has motor symptoms for > 4 years.
• Participant has advanced disease, as indicated by frequent falls or choking.
• Participant has structural brain abnormality on MRI.
• Participant has any significant neurological disorder other than MSA.
• Participant has an unstable medical or psychiatric illness.
• Participant has a contraindication to, or is unable to tolerate, MRI or lumbar puncture.

Where it is running

• University of California San Diego — La Jolla, California, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Columbia University Irving Medical Center — New York, New York, United States
• The Movement Disorder Clinic of Oklahoma — Tulsa, Oklahoma, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• St Vincent's Hospital (Sydney) — Darlinghurst, New South Wales, Australia
• Westmead Hospital — Westmead, New South Wales, Australia
• The Alfred Hospital — Melbourne, Victoria, Australia
• CHU de Toulouse/Hôpital Pierre-Paul Riquet — Toulouse, Haute-Garonne, France
• CHU de Bordeaux/Groupe Hospitalier Pellegrin — Bordeaux, France
• CHU de Marseille/Hôpital de la Timone — Marseille, France
• CHU/HU Pitié Salpêtrière — Paris, Île-de-France Region, France
• IRCCS Istituto Delle Scienze Neurologiche di Bologna — Bologna, Bologna, Italy
• Policlinico di Milano — Milan, Italy
• Azienda Ospedaliero-Universitaria Pisana — Pisa, Italy
• AOU San Giovanni di Dio Ruggi d'Aragona — Salerno, Italy
• New Zealand Brain Research Institute — Christchurch, New Zealand
• Auckland City Hospital — Grafton, New Zealand
• University College London — London, England, United Kingdom
• Newcastle University — Newcastle upon Tyne, England, United Kingdom
• Salford Royal Hospital — Salford, England, United Kingdom
• Queen Elizabeth University Hospital — Glasgow, Scotland, United Kingdom

Full record on ClinicalTrials.gov

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