Aspiration in Acute Respiratory Failure Survivors 2

Recruiting now · Not applicable

Conditions studied: Dysphagia, Aspiration

In brief

The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.

Key facts

Study ID

NCT05108896

Run by

University of Colorado, Denver

People needed

855

Starts

2021-12-15

Expected to finish

2025-12-15

Last updated by the study team

2024-10-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission to an ICU.
• Mechanical ventilation with an endotracheal tube for greater than 48 hours.

You may not qualify if…

• Likely persistent contraindications to enteral/oral nutrition administration.
• Pre-existing history of dysphagia or aspiration.
• Pre-existing or acute primary central or peripheral neuromuscular disorder.
• Presence of a chronic tracheostomy (present prior to ICU admission).
• Pre-existing head and neck cancer or surgery.
• Coagulopathy resulting in uncontrolled nasal or pharyngeal bleeding.
• Delirium for more than 96 hours after extubation as assessed by Confusion Assessment Method (CAM-ICU).
• Extubated for greater than 96 hours.
• Inability to obtain informed consent from patient or an appropriate surrogate.
• Age < 18 years.

Where it is running

• Stanford Univerity — Stanford, California, United States (enrolling)
• University of Colorado — Aurora, Colorado, United States (enrolling)
• Yale University — New Haven, Connecticut, United States (enrolling)
• Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
• Boston University — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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