Early Videocapsule Endoscopy for Upper Gastrointestinal Bleeding

Recruiting now · Not applicable

Conditions studied: Small Bowel Bleeding

In brief

The objective of this study is to determine whether early video capsule endoscopy (VCE) immediately after a negative gastroscopy in the setting of suspected upper gastrointestinal bleeding (UGIB) improves patient outcomes as compared to the standard approach which typically involves performing colonoscopy prior to small bowel investigations. We aim to examine the differences in diagnostic yield, total number of procedures, length of hospitalization, mortality rates, and healthcare cost between the two groups.

Key facts

Study ID

NCT05108844

Run by

University of Alberta

People needed

70

Starts

2021-09-01

Expected to finish

2026-11-30

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• New onset of acute gastrointestinal bleeding defined as:
• The presence of melena/maroon stool on physical exam OR history of melena/maroon stool within 48 hours of emergency room presentation PLUS
• Hemoglobin drop of ≥ 20 g/L from patient's baseline
• Have capacity to consent
• Hemodynamically stable (i.e. blood pressure >100/60 or pulse <110 at the time of consent)
• Initial gastroscopy negative for active bleeding or potential bleeding source

You may not qualify if…

• Inability to provide consent due to lack of capacity, language barrier or other reasons
• Pregnant women
• Prior history of small bowel surgery
• Prior history of Crohn's disease
• Prior history of small bowel or colonic strictures
• Prior history of abdominal radiation

Where it is running

• University of Alberta Hospital — Edmonton, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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