Effect of Plasma Ceramides on Peripheral Vascular Function

Completed · Not applicable

Conditions studied: Peripheral Vascular Disease, Lipid Disorder, Endothelial Dysfunction

In brief

The goal of this clinical trial is to determine the effect of elevated plasma ceramides on peripheral vascular function. Subjects will consume a high fat meal consisting of long chain fatty acids (to increase plasma ceramides) or medium chain fatty acids (control). Subjects' vascular function will be assessed with laser Doppler flowmetry to measure their artery function and with the CytoCam device to assess their peripheral microvascular endothelial function.

Key facts

Study ID

NCT05107869

Run by

Medical College of Wisconsin

People needed

23

Starts

2023-05-01

Expected to finish

2025-10-01

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Health adults aged 18-40 years
• English-speaking only
• Not pregnant

You may not qualify if…

• Healthy individuals under 18 years or over 40 years of age
• Non-English speaking
• Pregnant individuals
• Heart rate <60 or >100
• Systolic blood pressure <100 or >160
• Subjects with visible open sores or wounds in mouth
• Lactose intolerant or allergy to dairy products
• Diabetes Mellitus
• Coronary Artery Disease
• High blood pressure
• High cholesterol
• Heart failure
• Current tobacco use
• Chemotherapy within the last 6 months

Where it is running

• Froedtert Hospital — Wauwatosa, Wisconsin, United States

Full record on ClinicalTrials.gov

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