A Study of NX-1607 in Adults With Advanced Malignancies
Recruiting now · Phase 1
Conditions studied: Ovarian Cancer, Epithelial, Gastric Cancer, GastroEsophageal Junction (GEJ) Cancer, Head and Neck Squamous Cell Carcinoma, Metastatic or Unresectable Melanoma, Non-small Cell Lung Cancer (NSCLC), Metastatic Castration-resistant Prostate Cancer (mCRPC), Malignant Pleural Mesothelioma (MPM), Triple Negative Breast Cancer (TNBC), Metastatic Urothelial Carcinoma, Cervical Cancer, Diffuse Large B Cell Lymphoma (DLBCL), Richter Transformation, Microsatellite Stable Colorectal Carcinoma
In brief
This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-1607 in patients with advanced malignancies.
Key facts
- Study ID
- NCT05107674
- Run by
- Nurix Therapeutics, Inc.
- People needed
- 345
- Starts
- 2021-09-29
- Expected to finish
- 2028-02-28
- Last updated by the study team
- 2025-09-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Northern Centre for Cancer Care — Newcastle, United Kingdom (enrolling)
- University of Southern California — Los Angeles, California, United States (enrolling)
- University of California, San Francisco — San Francisco, California, United States (enrolling)
- University of Colorado School of Medicine — Aurora, Colorado, United States (enrolling)
- University of Chicago — Chicago, Illinois, United States (enrolling)
- University of North Carolina — Chapel Hill, North Carolina, United States (enrolling)
- University of Oklahoma — Oklahoma City, Oklahoma, United States (enrolling)
- MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- University of Virginia — Charlottesville, Virginia, United States (enrolling)
- Fred Hutchinson Cancer Center — Seattle, Washington, United States (enrolling)
- Royal Marsden Hospital NHS Foundation Trust — Sutton, Surrey, United Kingdom (enrolling)
- Addenbrookes Cambridge University Hospital — Cambridge, United Kingdom (enrolling)
- Beatson West of Scotland Cancer Centre — Glasgow, United Kingdom (enrolling)
- Sarah Cannon Research Institute — London, United Kingdom (enrolling)
- The Christie NHS Foundation Trust — Manchester, United Kingdom (enrolling)
- Churchill Hospital — Oxford, United Kingdom
- City of Hope — Duarte, California, United States
Full record on ClinicalTrials.gov
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