Variation in Humeral Head Bone Marrow Characteristics With Rotator Cuff Repair Healing

Running, not enrolling

Conditions studied: Rotator Cuff Tears, Rotator Cuff Repairs

In brief

This study investigates correlations between humeral head bone marrow characteristics and tendon healing of rotator cuff repairs. The anticipated results would motivate future research aimed to investigate local enrichment or transplantation of connective tissue progenitor cells to augment rotator cuff repair and the pursuit of novel methods of bone marrow screening to preoperatively identify patients with bone marrow characteristics related to rotator cuff repair success or failure.

Key facts

Study ID

NCT05106088

Run by

The Cleveland Clinic

People needed

50

Starts

2021-11-22

Expected to finish

2029-06-30

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males or females
• 18-75 years
• 1-5 cm full thickness tear of the supraspinatus and/or infraspinatus tendon(s) that is fully reparable by double row technique as confirmed at surgery

You may not qualify if…

• A 35 point exclusion criteria covers a variety of shoulder, musculoskeletal and general heath related conditions such as:
• prior shoulder surgery (including rotator cuff repair)
• symptomatic cervical spine disease
• a frozen shoulder-- defined as a loss of passive range of motion (ROM) of more than 20° in any plane compared to the contralateral shoulder
• advanced (grade 3 or 4) glenohumeral arthritis
• worker's compensation cases
• isolated subscapularis tears.

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.