M1 Schizophrenia PET Study

Completed · Phase 1

Conditions studied: Schizophrenia, Schizoaffective Disorder, Healthy

In brief

This exploratory study seeks to examine M1 receptor availability in SZ patients and to relate M1 receptor availability to proximal and distal measures of cognitive performance, namely evoked ɣ oscillations in the EEG and verbal memory. Furthermore, the relationship between hippocampal \[11C\]EMO availability (BPND), evoked ɣ oscillations, verbal memory, and measures of illness severity will be explored.

Key facts

Study ID

NCT05105542

Run by

Yale University

People needed

18

Starts

2021-04-20

Expected to finish

2023-10-31

Last updated by the study team

2024-11-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women aged 18- 65 years that are physically and mentally healthy with the exception of DSM-5 schizophrenia or schizoaffective disorder diagnosis
• Subjects with no metal in the body that may pose a risk during MRI scanning
• No significant medical history, including head trauma and bleeding disorders

You may not qualify if…

• Men and women with a history or presence of clinically significant medical conditions
• People who suffer from claustrophobia, have MRI incompatible implants, or other contraindications for MRI and PET scans

Where it is running

• Connecticut Mental Health Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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