Immunomodulatory Effects of Fasting in Healthy Adults

Recruiting now · Not applicable

Conditions studied: Fasting

In brief

This is a clinical trial assessing the effects of fasting on the immune system in healthy adults. Immune profiling, gene expression profiling, and flow cytometry on peripheral blood mononuclear cells (PBMCs) will be performed and we hypothesize that a period of fasting will alter the immune system in healthy adults.

Key facts

Study ID

NCT05104502

Run by

University of California, Davis

People needed

4

Starts

2022-03-25

Expected to finish

2026-09-01

Last updated by the study team

2026-07-06

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: 20-40 years, to constitute a young study population
• Gender: male subjects, to control for gender differences
• BMI: 19-27 kg/m2 to constitute a normal/healthy weight population
• Weight: 120 lbs or more
• Fasting glucose: 70-100 mg/dL, to ensure that fasting can be tolerated without inducing dangerously low levels of blood glucose
• Subjects must be willing to undergo a period of 36 hours of water-only fasting
• Subjects must be willing to collect samples of each bowel movement produced throughout the entire study period for microbiome analysis
• Subjects must be willing to collect blood pricks for blood glucose levels using a Contour Next One Blood Glucose Testing Kit during the fasting stage of the study protocol.

You may not qualify if…

• Current smoking
• Anemia
• Pregnancy or current breastfeeding
• Chronic diseases including diabetes mellitus, thyroid disease, metabolic syndrome, cancer, or previous cardiovascular events
• Gastrointestinal diseases including irritable bowel syndrome, Crohn's disease, ulcerative colitis, celiac disease
• Consumption of >1 alcoholic drink/day
• Extreme dietary or exercise patterns
• Recent weight fluctuations (greater than 10% in the last six months)
• Regular use of over-the-counter allergy or pain medications (>1/week)
• Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones
• Use of hormonal birth control including oral contraception pills, hormonal IUDs or rings, or hormonal birth control patches

Where it is running

• UC Davis — Sacramento, California, United States (enrolling)

Full record on ClinicalTrials.gov

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