A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder

Completed · Phase 2 · Has a placebo group

Conditions studied: Post-Traumatic Stress Disorder

In brief

This study is open to people aged 18 to 65 who have post-traumatic stress disorder. The purpose of this study is to find out whether a medicine called BI 1358894 improves symptoms in people with post-traumatic stress disorder. Participants are put into 2 groups randomly, which means by chance. Participants take BI 1358894 or placebo as tablets every day for 2 months. Placebo tablets look like BI 1358894 tablets but do not contain any medicine. Participants are in the study for about 3 months. During this time, they visit the study site about 8 times and get about 4 phone calls from the trial staff. During the study, participants answer questions in interviews and complete questionnaires so the doctors can check whether their symptoms change. The doctors also regularly check participants' health and take note of any unwanted effects.

Key facts

Study ID

NCT05103657

Run by

Boehringer Ingelheim

People needed

318

Starts

2021-12-07

Expected to finish

2023-11-20

Last updated by the study team

2024-11-07

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Established diagnosis of Post-Traumatic Stress Disorder (PTSD) corresponding to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria
• Time since index event according to Life Events Checklist / Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Criterion A at least 3 months before screening visit
• PTSD must be the clinically pre-dominant disorder, as per investigator´s judgement. Other comorbid psychiatric disorders are allowed, unless specifically excluded in the exclusion criteria
• A total severity score of ≥ 33 on the PTSD Checklist for DSM-5 (PCL-5) at the screening visit
• Moderate to severe PTSD confirmed by CAPS-5 range ≥ 30 confirmed at screening visit
• Male or female patients, 18 to 65 years of age, both inclusively at the time of informed consent
• Women who are of child-bearing potential (WOCBP) must be able and willing to use two methods of contraception, as confirmed by the investigator, which include one highly effective method of birth control per International Council on Harmonisation (ICH) M3 (R2) that result in a low failure rate of less than 1%, plus one additional barrier method
• Signed and dated written informed consent in accordance with International Council on Harmonisation - Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial

You may not qualify if…

• Corresponding to DSM-5, had ever met diagnostic criteria for schizophrenia, schizoaffective disorder, schizophreniform disorder, bipolar disorder, delusional disorder, brief psychotic disorder or any other psychotic disorder as well as Major Depressive Disorder (MDD) with psychotic features as assessed by the Mini-International Neuropsychiatric Interview (MINI) at the time of screening
• Any psychiatric or non-psychiatric medical condition likely to negatively impact trial participation as per the judgement of the investigator
• Acute stress disorder or significant traumatic event within 3 months prior to the screening visit
• Use of stimulant medications within 3 months prior to the screening visit (Attention Deficit Hyperactivity Disorder (ADHD) diagnosis alone is not exclusionary)
• Severe traumatic brain injury (life-time) or moderate traumatic brain injury within the last 2 years prior to screening visit or 3 months for mild traumatic brain injury, based on the Ohio State University Traumatic Brain Injury (TBI) Identification Method Short Form. Or history of traumatic brain injury that would impact ability to complete trial assessments or procedures according to investigator.
• Current treatment with trauma focused therapy (i.e. Cognitive Processing Therapy (CPT), Prolonged Exposure Therapy (PE), Eye Movement Desensitization and Reprocessing (EMDR)). A psychotherapy in type, intensity and/or frequency other than trauma focused therapy is allowed if stable within the last 8 weeks prior to screening and not anticipated to change during the entire course of the trial. Long-term psychotherapy is permitted as long as patients are not in an exposure phase during the trial.
• Diagnosis of a current moderate or severe alcohol use disorder according to MINI within 3 months prior to screening visit (mild alcohol use disorder (AUD) and patients in early remission = criterion not met for between 3 \& 12 months are allowed) Further exclusion criteria apply

Where it is running

• Behavioral Research Specialists, LLC — Glendale, California, United States
• ASCLEPES Research Centers, P.C. dba Alliance Research — Long Beach, California, United States
• CalNeuro Research Group Inc. — Los Angeles, California, United States
• Artemis Institute for Clinical Research — Riverside, California, United States
• Artemis Institute for Clinical Research, LLC — San Diego, California, United States
• Clinical Innovations Inc. — Santa Ana, California, United States
• California Neuroscience Research — Sherman Oaks, California, United States
• Collaborative Neuroscience Research, LLC — Torrance, California, United States
• Mountain Mind. LLC — Denver, Colorado, United States
• CNS Clinical Research - Coral Springs — Coral Springs, Florida, United States
• Innovative Clinical Research — Lauderhill, Florida, United States
• Miami Dade Medical Research Institute, LLC — Miami, Florida, United States
• Medical Research Group of Central Florida — Orange City, Florida, United States
• Elixia PHC, LLC — St. Petersburg, Florida, United States
• Institute for Advanced Medical Research — Alpharetta, Georgia, United States
• Emory University — Atlanta, Georgia, United States
• American Medical Research — Chicago, Illinois, United States
• University of Chicago — Chicago, Illinois, United States
• Pharmasite Research, Incorporated — Baltimore, Maryland, United States
• Boston Clinical Trials — Boston, Massachusetts, United States
• Sisu BHR, LLC — Springfield, Massachusetts, United States
• NeuroBehavioral Medicine Group — Bloomfield Hills, Michigan, United States
• Hassman Research Institute — Berlin, New Jersey, United States
• Center For Emotional Fitness — Cherry Hill, New Jersey, United States
• Woodland International Research Group, Inc. — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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