Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.

Completed

Conditions studied: Circulatory Shock, Cardiovascular Shock

In brief

This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery. Participants will be administered a topical sublingual nitroglycerin solution and assessed for changes microcirculatory blood flow using incident dark field microscopy.

Key facts

Study ID

NCT05102734

Run by

University of Pennsylvania

People needed

44

Starts

2021-09-01

Expected to finish

2022-03-01

Last updated by the study team

2024-04-01

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients receiving elective CABG or valvular surgery requiring cardiopulmonary bypass
• Receiving postoperative catecholamine therapy to maintain a MAP > 65mmHg, cardiac index > 2 despite initial fluid resuscitation
• Invasive hemodynamic monitoring

You may not qualify if…

• Surgical hemorrhage
• Unable to tolerate sublingual microcirculatory flow imaging
• Known intolerance or allergy to nitroglycerin
• Inadequate microcirculation imaging (based on Massey Score)

Where it is running

• Hospital of the University of the Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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