A Retrospective Protocol Empowering Precision Research in Colorectal Cancer (ALFAOMEGA-RETRÒ)

Recruiting now

Conditions studied: Colorectal Cancer

In brief

ALFAOMEGA-RETRÒ will be exploited to retrospectively collect clinical and imaging data and archival samples to be used for validation and correlative studies on markers discovered by cutting-edge translational projects within the AIRC5x1000 program "Insights into the evolving heterogeneity of colorectal cancer (CRC): from mechanism to therapies" (an ongoing multi-institutional research program).

Key facts

Study ID

NCT05101382

Run by

IFOM ETS - The AIRC Institute of Molecular Oncology

People needed

500

Starts

2020-10-28

Expected to finish

2026-12-01

Last updated by the study team

2025-08-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically-confirmed diagnosis of colorectal cancer (any stage).
• Age >18 years at the time of diagnosis.
• Availability of clinically-annotated radio-imaging data and/or diagnostic Formalin-Fixed Paraffin Embedded (FFPE) blocks (surgical resections and/or tumor biopsies), or at least 10 slides (preferably 20). FFPE tissue blocks are always preferred to slides.
• Verification that the patient could not be reached for informed consent in accordance with applicable national regulations.

You may not qualify if…

• if inclusion criteria are not met

Where it is running

• INCLIVA - Instituto de Investigatión Sanitaria — Valencia, Spain (enrolling)
• Fondazione IRCCS, Istituto Nazionale dei Tumori — Milan, MI, Italy (enrolling)
• Niguarda Cancer Center - ASST Grande Ospedale Metropolitano Niguarda — Milan, MI, Italy (enrolling)
• IRCCS Istituto Clinico Humanitas — Milan, MI, Italy (enrolling)
• Istituto Oncologico Veneto (IOV) — Padua, PD, Italy (enrolling)
• Azienda Ospedaliero Universitaria Pisana — Pisa, Pisa, Italy (enrolling)
• Istituto di Candiolo - IRCCS — Candiolo, TO, Italy (enrolling)
• Azienda Ospedaliero Universitaria San Luigi Gonzaga — Orbassano, TO, Italy (enrolling)
• Ospedale Policlinico San Martino — Genova, GE, Italy (enrolling)
• Institut Català D'Oncologia (ICO) — L'Hospitalet de Llobregat, Barcelona, Spain (enrolling)
• Hospital del Mar - Parc de Salut Mar — Barcelona, Spain (enrolling)
• Vall d'Hebron Institute of Oncology (VHIO) — Barcelona, Spain (enrolling)
• Azienda Ospedaliera Ordine Mauriziano — Torino, TO, Italy

Full record on ClinicalTrials.gov

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