Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI

Running, not enrolling · Phase 4

Conditions studied: Osteoporosis, Spinal Cord Injuries

In brief

The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of denosumab administration alone.

Key facts

Study ID

NCT05101018

Run by

James J. Peters Veterans Affairs Medical Center

People needed

40

Starts

2021-11-01

Expected to finish

2027-11-01

Last updated by the study team

2025-09-17

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Traumatic motor-complete or incomplete SCI C4-L2 (AIS grade A-C);
• Duration of SCI less than 6 months;
• Males and females (premenopausal) between the ages of 18 and 55 years old; and a safe range of BMD right above the knee as determined by study staff review;

You may not qualify if…

• Active and/or history of coronary heart disease or stroke;
• Bone cancer;
• Long-bone fracture of the leg within the past year;
• History of prior bone disease (for example, Paget's hyperparathyroidism, osteoporosis, etc.);
• Postmenopausal women;
• Men with known low functioning tests before SCI;
• Drugs geared toward increasing BMD longer than a six month duration after SCI;
• As determined by study staff review of my medication history of glucocorticoid administration longer than three months duration within the last year
• Abnormalities of my endocrine glands such as hyperthyroidism, Cushing's disease or syndrome, etc.;
• Severe underlying chronic disease (for example chronic obstructive pulmonary disease (COPD), end-stage heart disease, chronic renal failure);
• Heterotopic ossification (HO) of the distal femur (the knee end of the thigh bone). HO is a condition where bone tissue forms outside of the skeleton. If HO is found in any other area than the distal femur it will not prevent my participation in the study.;
• History of chronic alcohol abuse;
• Diagnosis of hypercalcemia (high levels of calcium in the blood);
• Pregnancy;
• As determined by study staff review of my medications a bisphosphonate for heterotopic ossification (HO), or other medications to treat osteoporosis other than calcium and vitamin D;
• Current diagnosis of cancer or history of cancer;
• As determined by study staff review of my medications, prescribed moderate or high dose corticosteroids (>40 mg/d prednisone or an equivalent dose of other corticosteroid medication) for longer than one week, not including drug administered to preserve neurological function at the time of acute SCI; and
• Life expectancy less than 5 years.

Where it is running

• Kessler Institute for Rehabilitation — West Orange, New Jersey, United States
• James J. Peters VA Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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