A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Running, not enrolling · Phase 3
Conditions studied: Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma
In brief
The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.
Key facts
- Study ID
- NCT05100862
- Run by
- BeOne Medicines
- People needed
- 799
- Starts
- 2022-03-10
- Expected to finish
- 2030-06-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Kaiser Permanente Southern California — Irvine, California, United States
- Cancer and Blood Specialty Clinic — Los Alamitos, California, United States
- Los Angeles Cancer Network — Los Angeles, California, United States
- Valkyrie Clinical Trials — Los Angeles, California, United States
- UCLA Hematologyoncology — Los Angeles, California, United States
- Scripps Health — San Diego, California, United States
- Sharp Healthcare Sharp Memorial Hospital — San Diego, California, United States
- Baptist Md Anderson Cancer Center — Jacksonville, Florida, United States
- Ascension Sacred Heart — Pensacola, Florida, United States
- Northwest Georgia Oncology Centers Marietta — Marietta, Georgia, United States
- Cancer Care Specialists of Illinois — Decatur, Illinois, United States
- Fort Wayne Medical Oncology and Hematology — Fort Wayne, Indiana, United States
- Mission Cancer and Blood — Waukee, Iowa, United States
- Cotton Oneil Cancer Center — Topeka, Kansas, United States
- Cancer Center of Kansas — Wichita, Kansas, United States
- Baptist Health Lexington — Lexington, Kentucky, United States
- Christus Highland Cancer Treatment Center — Shreveport, Louisiana, United States
- Luminis Health Anne Arundel Medical Center — Annapolis, Maryland, United States
- The University of Maryland Greenebaum Comprehensive Cancer Center — Baltimore, Maryland, United States
- Ascension St Agnes Hospital — Baltimore, Maryland, United States
- American Oncology Partners of Maryland Pa — Bethesda, Maryland, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- Corewell Health the Michigan Cancer Consortium — Grand Rapids, Michigan, United States
- Hattiesburg Hematology and Oncology Clinic — Hattiesburg, Mississippi, United States
- Ucsf Fresno University of California San Francisco Fresno — Fresno, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.