Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease

Recruiting now · Not applicable

Conditions studied: Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention

In brief

Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD. EndeavorRx (Akili Interactive Labs: Boston, MA) is an FDA-approved home-based, electronic attentional-control training program designed to treat attention problems in youth. Users access EndeavorRx on a tablet device for 25-30 minutes each day, 5 days per week, for 4 weeks. The program involves training in a game-like environment that repeatedly challenges attentional-control abilities and adapts to user performance, becoming more difficult over time as performance improves. This pilot study is examining the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a sample of 20 children with SCD ages 8-16 who are being treated with chronic blood transfusion therapy.

Key facts

Study ID

NCT05099874

Run by

Children's National Research Institute

People needed

20

Starts

2022-12-20

Expected to finish

2025-12-01

Last updated by the study team

2025-01-10

Who can join

Age: 8 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of SCD
• ages 8-16 years
• maintained on monthly blood transfusions consistently for at least 3 months.
• patients will be proceed to the intervention phase only if they have a T-score > 75th percentile for Omission Errors on the Conners' Continuous Performance Test, 3rd Edition (CPT-3) or a T-score > 75th percentile for the Inattention subscale of the ADHD Rating Scale, Fifth Edition (ADHD-RS-V).

You may not qualify if…

• estimated Intelligence Quotient < 70
• motor, visual, or auditory impairment that prevents computer use
• known diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in cognitive training
• history of photosensitive seizures
• insufficient English fluency.

Where it is running

• Children's National Hospital — Washington D.C., District of Columbia, United States (enrolling)

Full record on ClinicalTrials.gov

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