End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation
Recruiting now
Conditions studied: Idiopathic Pulmonary Fibrosis, Mechanical Ventilation Pressure High
In brief
Patients with pulmonary fibrosis and associated usual interstitial pneumonia that require mechanical ventilation for acute respiratory failure experience poor clinical outcomes. This may be influenced by the unfavorable interaction between the fibrotic lung and the stress and strain stimuli generated during controlled ventilation. Although there is no consensus on how to ventilate these patients, much of the recommendations followed in clinical practice are taken from the experience on patients with acute respiratory distress syndrome. Among these, measuring the esophageal pressures and adjusting positive-end expiatory pressure to make trans-pulmonary pressures positive can decrease atelectasis, derecruitment of lung, and cyclical opening and closing of airways and alveoli, thus optimizing lung mechanics and oxygenation. The effect of this strategy on the fibrotic lung has not yet been documented. With this observational study we aim at documenting the effect of PEEP titration maneuver based on end-expiratory trans-pulmonary pressure on lung mechanics of patients with pulmonary fibrosis and UIP pattern,
Key facts
- Study ID
- NCT05098717
- Run by
- University of Modena and Reggio Emilia
- People needed
- 40
- Starts
- 2023-02-08
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2025-04-25
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- pulmonary fibrosis with UIP pattern
- subjected to endotracheal intubation and controlled mechanical ventilation for acute respiratory failure
- candidate to a trial of PEEP titration according to positive end expiratory pressure.
You may not qualify if…
- chest wall deformities
- chronic obstructive pulmonary disease
Where it is running
- Azienda Ospedaliero Universitaria Policlinico di Modena — Modena, Italy (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.