Medrol Dosepak for Outpatient Total Knee Arthroplasty

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Total Knee Arthroplasty

In brief

The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper starting on postoperative day 1 (POD 1) following TKA will be associated with improved pain and decreased opioid use, nausea, and complications at POD1-7, as compared to similar patients who receive placebo. Additionally, those taking methylprednisolone will report decreased pain and greater objective functional outcomes at 3 and 6 weeks postoperatively as compared to controls.

Key facts

Study ID

NCT05097976

Run by

Rush University Medical Center

People needed

420

Starts

2022-03-01

Expected to finish

2027-12-01

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Any patient undergoing primary TKA with a diagnosis of osteoarthritis
• ≥ 18 years old
• Willingness to undergo randomization

You may not qualify if…

• Reported chronic corticosteroid or opiate use
• Suspected or confirmed periprosthetic joint infection
• Revision TKA
• Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, or post-traumatic arthritis
• American Society of Anesthesiologists (ASA) score ≥ 4
• Reported history of liver disease, renal disease, or diabetes mellitus
• Current systemic fungal infection or other local infection
• Immunocompromised or immunosuppressed
• Current peptic ulcer disease
• History of hypothyroidism, psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis
• Women with reported current pregnancy
• Known hypersensitivity to methylprednisolone
• ≤ 18 years old
• Inability to take oral medications
• Unable to provide consent

Where it is running

• Rush Oak Brook Outpatient Center — Oak Brook, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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