PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
Recruiting now · Phase 2
Conditions studied: High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Recurrent Medulloblastoma
In brief
This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) as well as recurrent medulloblastoma (MB). PEP-CMV is a vaccine mixture of a peptide referred to as Component A. Component A is a synthetic long peptide (SLP) of 26 amino acid residues from human pp65. The SLPs encode multiple potential class I, class II, and antibody epitopes across several haplotypes. Component A will be administered as a stable water:oil emulsion in Montanide ISA 51. Funding Source - FDA OOPD
Key facts
- Study ID
- NCT05096481
- Run by
- Nationwide Children's Hospital
- People needed
- 120
- Starts
- 2024-07-18
- Expected to finish
- 2030-06-15
- Last updated by the study team
- 2026-05-11
Who can join
Age: 3 and older, up to 39. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Seattle Children's Hospital — Seattle, Washington, United States (enrolling)
- Children's National Medical Center — Washington D.C., District of Columbia, United States (enrolling)
- Nicklaus Children's Hospital — Miami, Florida, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
- Texas Children's Hospital — Houston, Texas, United States (enrolling)
- Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)
- C.S. Mott Children's Hospital — Ann Arbor, Michigan, United States (enrolling)
- St. Louis Children's Hospital — St Louis, Missouri, United States (enrolling)
- Duke Cancer Center — Durham, North Carolina, United States (enrolling)
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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