Cerebellar Stimulation for Aphasia Rehabilitation
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Stroke
In brief
The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in helping people recover from aphasia as well as predict who is likely to respond to cerebellar tDCS.
Key facts
- Study ID
- NCT05093673
- Run by
- Johns Hopkins University
- People needed
- 60
- Starts
- 2021-10-25
- Expected to finish
- 2028-04-01
- Last updated by the study team
- 2026-03-20
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Chronic ischemic or hemorrhagic left hemisphere stroke
- Fluent speaker of English by self-report
- Age 18 or older
- 6 months post onset of stroke
- Diagnosis of aphasia and naming impairment using the Western Aphasia Battery-Revised
You may not qualify if…
- Lesion in the right cerebellum
- Previous neurological disorder (other than stroke) affecting the brain, or any other neurodegenerative disorder or psychiatric disorder
- Seizures during the previous 6 months
- Uncorrected visual loss or hearing loss by self-report
- Use of medications that lower the seizure threshold (e.g., methylphenidate)
- Use of N-methyl-D-aspartate (NMDA) antagonists (e.g., memantine)
- History of brain surgery or any metal in the head
- Severely impaired auditory comprehension (lower than 2 on the Comprehension subscore on the Western Aphasia Battery-Revised)
- Severely limited verbal output (lower than 2 on the Spontaneous Speech rating scale on the Western Aphasia Battery-Revised)
- Individuals with severe claustrophobia, cardiac pacemakers or ferromagnetic implants, and pregnant women will be excluded from the MRI portion of the study.
Where it is running
- Johns Hopkins Hospital — Baltimore, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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