Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer

Recruiting now · Phase 2

Conditions studied: Pancreatic Cancer

In brief

A phase II study combining pembrolizumab with olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden

Key facts

Study ID

NCT05093231

Run by

Cambridge University Hospitals NHS Foundation Trust

People needed

20

Starts

2025-02-26

Expected to finish

2028-01-01

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥ 18 years old
• Written informed consent
• Histologically or cytologically confirmed PDA
• Confirmation that the PDA has TMB >4 mutations/Mb, or dMMR gene mutation, or MSI-H by IHC. TMB status and dMMR can be obtained from either tissue, or blood.
• Radiologically confirmed stage 4 mPDA, with measurable disease
• Received no more than 1 prior systemic therapy regimen for unresectable (stage 3 or 4) PDA is allowed
• Measurable disease which has not been irradiated in prior radiotherapy
• Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
• Life expectancy >12 weeks from the date of screening assessment
• Adequate bone marrow function:
• Absolute neutrophil count (ANC) ≥1.5 x 109 /L
• Haemoglobin (Hb) ≥ 90 g/L
• Platelets ≥100 x 109 /L
• Adequate liver function:
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≤2.5 x upper limit of normal range (ULN), or <5 x ULN in the presence of liver metastases
• Total bilirubin <1.5 x ULN
• Adequate renal function defined as a calculated creatinine clearance by Cockcroft - Gault of ≥50 mL/min

You may not qualify if…

• Patients with resectable or locally advanced PDA
• Other invasive malignancies diagnosed within the last 2 years which have not been treated with curative intent
• Prior immune checkpoint inhibitors or PARP inhibitors. This includes any prior therapy with an anti-PD-1, or anti-PD-L1, or anti-PD-L2 agent, or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g, CTLA-4, OX 40, CD137)
• Requirement for non-physiological dose of daily oral steroids, or regular use of any other immunosuppressive agents; prednisolone dose of < 10mg (or equivalent steroid dose) is allowed. Use of inhaled or topical steroids is allowed.
• Significant acute or chronic medical or psychiatric condition, disease or laboratory abnormality, which in the judgment of the investigator would place the patient at undue risk or interfere with the trial. Examples include, but are not limited to:
• A history of chronic obstructive pulmonary disease, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis, cystic fibrosis or bronchiectasis affecting pulmonary function, causing breathlessness at rest
• Uncontrolled ischaemic heart or other cardiovascular event (myocardial infarction, new angina, stroke transient ischaemic attack, or new congestive cardiac failure) within the last 2 months
• Stable but significant cardiovascular disease defined by heart failure (New York Heart Association Functional Classification III or IV) or frequent angina
• Presence of active infection
• Cirrhotic liver disease, known HIV, chronic active or acute hepatitis B, or hepatitis C
• History of severe allergy or hypersensitivity reactions
• Autoimmune disease requiring chronic use of immunosuppressive agents.
• Replacement therapy using physiological doses for adrenal or pituitary insufficiency is allowed.
• Known additional malignancy that is progressing or has required active treatment within the past 3 years. Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ, excluding carcinoma in situ of the bladder, that have undergone potentially curative therapy are not excluded.
• Has known brain metastases and/or carcinomatous meningitis
• Has myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML) or with features suggestive of MDS/AML.
• Women who are pregnant, or plan to become pregnant or are lactating.
• Women of child-bearing potential and male patients who are unwilling to adhere to the contraception requirement from informed consent until the last dose of the trial treatment and for 120 days after the last dose of trial treatment.
• Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the trial medication.
• Concomitant use of known potent CYP3A4 inhibitors and inducers. Restrictions relating to concomitant medications are described in section 10.9. Please consider wash-out periods.
• Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to screening.
• Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients
• Has received prior radiotherapy within 2 weeks of start of study intervention. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted for palliative radiation (≤2 weeks of radiotherapy) to non-CNS disease.
• Has received a live vaccine or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed.
• Participant received colony-stimulating factors (e.g., granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM CSF] or recombinant erythropoietin) within 28 days prior to the first dose of study intervention.

Where it is running

• Monash Health — Melbourne, Australia (enrolling)
• Epworth Healthcare — Richmond, Australia (enrolling)
• Addenbrooke's Hospital — Cambridge, Cambridgeshire, United Kingdom (enrolling)
• Glan Clwyd Hospital — Bodelwyddan, United Kingdom (enrolling)
• Velindre Cancer Centre — Cardiff, United Kingdom (enrolling)
• University Hospitals Coventry and Warwickshire — Coventry, United Kingdom (enrolling)
• Beatson West of Scotland Cancer Centre — Glasgow, United Kingdom (enrolling)
• St James' University Hospital — Leeds, United Kingdom (enrolling)
• Clatterbridge Cancer Centre — Liverpool, United Kingdom (enrolling)
• Guy's and St Thomas' NHS Foundation Trust — London, United Kingdom (enrolling)
• Royal Free Hospital — London, United Kingdom (enrolling)
• University College London Hospitals NHS Foundation Trust — London, United Kingdom (enrolling)
• The Christie — Manchester, United Kingdom (enrolling)
• Milton Keynes University Hospital — Milton Keynes, United Kingdom (enrolling)
• Norfolk and Norwich University Hospital — Norwich, United Kingdom (enrolling)
• Nottingham University Hospitals NHS Foundation Trust — Nottingham, United Kingdom (enrolling)
• Derriford Hospital — Plymouth, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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