Are Adductor Canal Blocks With Bupivacaine and Added Magnesium Better at Managing Post-operative Pain Than Bupivacaine and Added Buprenorphine in Patients Undergoing Same-day Discharge Total Knee Arthroplasty?
Status unconfirmed · Not applicable
Conditions studied: Post-operative Pain, Acute, Opioid Use
In brief
The purpose of this study is to compare the use of magnesium and bupivacaine to buprenorphine and bupivacaine in post-operative adductor canal blocks (ACB); the study will determine if one combination can result in decreased opioid consumption and improved pain management for patients after same-day discharge total knee arthroplasty (TKA) . The investigators will assess whether the addition of magnesium to bupivacaine will decrease visual analog scale (VAS) pain scores, decrease post-operative total opioid consumption (oral morphine equivalents), decrease the incidence of post-operative nausea and vomiting (PONV), and improve patient satisfaction in comparison to when buprenorphine is added to bupivacaine.
Key facts
- Study ID
- NCT05091138
- Run by
- Wayne State University
- People needed
- 100
- Starts
- 2021-10-12
- Expected to finish
- 2022-10-01
- Last updated by the study team
- 2021-10-25
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients undergoing unilateral primary total knee arthroplasty with spinal anesthetic and MAC followed by a unilateral adductor canal block with ultrasound guidance.
You may not qualify if…
- Patients on chronic anticoagulation upon admission
- Patients with significant genetic or acquired clotting/bleeding disorders (hemophilia, DIC, etc.) or significant platelet dysfunction
- Patients with prior back surgery or leg surgery that precludes spinal or regional anesthesia
- Infection at sites for regional/spinal anesthesia
- Allergy to local anesthetics
Where it is running
- St. Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States (enrolling)
Full record on ClinicalTrials.gov
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