Preventing High Blood Sugar in People Being Treated for Metastatic Breast Cancer

Running, not enrolling · Phase 2

Conditions studied: Breast Cancer, Breast Cancer Stage IV, Metastatic Breast Cancer

In brief

The purpose of this study to find out whether a very low carbohydrate diet (ketogenic diet), a low carbohydrate diet, or the study drug canagliflozin can prevent high blood sugar and may improve the effectiveness of cancer therapy in people who are receiving standard treatment with alpelisib and fulvestrant for their metastatic PIK3CA-mutant breast cancer.

Key facts

Study ID

NCT05090358

Run by

Memorial Sloan Kettering Cancer Center

People needed

15

Starts

2021-10-08

Expected to finish

2026-10-08

Last updated by the study team

2025-10-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed metastatic HR-positive, HER2-negative breast cancer. HR positive is defined by ER status >10% immunohistochemical (IHC) staining of any intensity. HER2 negativity is defined as the following as per the 2018 American Society of
• Clinical Oncology and College of American Pathologists guidelines:
• IHC score of 0 or 1+ or
• Single-probe average HER2 copy number of <4 signals/cell or
• Dual-probe HER2/CEP17 ratio <2 with an average HER2 copy number of <4 signals/cell or
• IHC 0, 1+, or 2+ and dual-probe HER2/CEP17 ratio ≥2 with an average HER2 copy number of <4 signals/cell or
• IHC 0 or 1+ and dual-probe HER2/CEP17 ratio <2 with an average HER2 copy number of ≥6 signals/cell or
• IHC 0 or 1+ and dual-probe HER2/CEP17 ratio <2 with an average HER2 copy number of ≥4 and <6 signals/cell.
• Presence of one or more activating PIK3CA mutations in tumor tissue.
• Measurable or non-measurable disease per RECIST v1.1 OR at least one predominantly lytic bone lesion must be present.
• Written informed consent provided
• Female or male ≥18 years of age
• Adequate archived tumor tissue for the analysis of PIK3CA mutational status or evaluable circulating tumor DNA (ctDNA) for analysis of PIK3CA mutation status
• Recurrence or progression of disease during or after endocrine-based therapy
• Eastern Cooperative Oncology Group performance status of 0 or 1.
• Life expectancy ≥6 months.
• Adequate organ and marrow function as defined below:
• Hemoglobin ≥9.0 g/dL (without blood transfusion within 7 days of laboratory test used to determine eligibility)
• Absolute neutrophil count ≥1.5 × 109/L (without granulocyte colony stimulating factor support within 2 weeks of laboratory test used to determine eligibility)
• Platelet count ≥100 × 109/L (without transfusion within 2 weeks of laboratory test used to determine eligibility)
• Total bilirubin (TB) ≤1.0 × institutional upper limit of normal (ULN; Patients with known Gilbert's disease who have TB ≤3 × ULN may be enrolled)
• Aspartate transaminase/alanine transaminase ≤2.5 × ULN with normal alkaline phosphatase (≤5 × ULN for patients with liver metastases) OR ≤1.5 × ULN in conjunction with alkaline phosphatase >2.5 × ULN
• Creatinine ≤1.5 mg/dL.
• Fasting blood glucose ≤140 mg/dL and HbA1c <8% (both criteria have to be met) and not on anti-hyperglycemic medications other than metformin (i.e., metformin is allowable if fasting blood glucose and HbA1c parameters are met).
• Able to swallow oral medication.

You may not qualify if…

• Multiple prior lines of chemotherapy in the metastatic setting (One line of chemotherapy is allowed. Also prior treatment with CDK4/6 inhibitors is allowed)
• Currently participating in a study of an investigational agent
• Current participation in a formalized weight loss program or currently consuming a ketogenic diet
• Body mass index < 20 kg/m\^2
• Known hypersensitivity to alpelisib, fulvestrant, canagliflozin, or to any of the excipients of alpelisib or fulvestrant.
• Concurrent malignancy (basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or cervical cancer in situ that have undergone curative intent therapy are allowed)
• Type 1 diabetes mellitus
• Uncontrolled type 2 diabetes mellitus (hemoglobin A1c ≥8.0)
• Type 2 diabetes mellitus requiring treatment with a sulfonylurea, meglitinide, SGLT2 inhibitors or insulin.
• Vegetarian or vegan eating habits.
• Allergy or intolerance to egg, gluten, nut or milk protein that would interfere with adherence to diet.
• Individuals with impaired decision making capacity

Where it is running

• Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Suffolk - Commack (Limited protocol activity) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (All protocol Activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Weill Cornell Medical College (Data Collection & Data Analysis) — New York, New York, United States
• Memorial Sloan Kettering Nassau (Limited Protocol Activities) — Uniondale, New York, United States
• Ohio State University (Data Collection & Data Analysis) — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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