A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

Recruiting now

Conditions studied: Hematopoietic Cell Transplantation

In brief

This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the HCT setting as a contributor of significant morbidity and mortality.

Key facts

Study ID

NCT05090345

Run by

Duke University

People needed

500

Starts

2019-11-19

Expected to finish

2028-02-05

Last updated by the study team

2026-06-01

Who can join

Age: any, up to 26. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children, adolescents and young adults (AYA) 0-26 years of age undergoing HSCT.
• Recipients of autologous and allogeneic HSCT.
• Any preparative regimen.

You may not qualify if…

• Any patient who does not consent/assent to participation.
• Any patient for whom 5 mL blood sample(s) drawn at specified intervals would pose any more than minimal risk, as defined by institutional guidelines and at discretion of treating physician will be ineligible for biorepository banking.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Duke University — Durham, North Carolina, United States (enrolling)
• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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