ROSE-Longitudinal Assessment With Neuroimaging
Running, not enrolling
Conditions studied: Intracerebral Hemorrhage
In brief
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neuroimaging cohort of ROSE to obtain long-term neuroimaging and identical assessments longitudinally to address critical questions regarding the progressive decline of patients 12 to 24 months post intracerebral hemorrhage (ICH) with long term cognitive follow-up to 36 months on average. This proposal would represent the largest, and longest advanced neuroimaging and RNA-sequencing evaluation after ICH to date.
Key facts
- Study ID
- NCT05089331
- Run by
- State University of New York at Buffalo
- People needed
- 250
- Starts
- 2020-09-30
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-07-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or greater, fulfillment of the criteria for Deep, Subcortical or Lobar Intracerebral Hemorrhage
- No evidence of trauma, vascular malformation or aneurysm, or brain tumor as a cause of ICH.
- Ability of the patient or legal representative to provide informed consent
You may not qualify if…
- Brainstem or Cerebellar ICH
- Patients Severely Affected by the ICH, Early Mortality, Hospice, or Withdraw of Care NOT eligible for ROS
Where it is running
- University of Illinois Chicago — Chicago, Illinois, United States
- Baptist Health Louisville — Louisville, Kentucky, United States
- University of Maryland — Baltimore, Maryland, United States
- Columbia University — New York, New York, United States
- Duke University — Durham, North Carolina, United States
- University of Cincinnati — Cincinnati, Ohio, United States
- Houston Methodist — Houston, Texas, United States
Full record on ClinicalTrials.gov
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