Study to Assess the Effect of Ofatumumab in Treatment Naïve, Very Early RRMS Patients Benchmarked Against Healthy Controls.
Completed · Phase 4
Conditions studied: Relapse Remitting Multiple Sclerosis
In brief
This study evaluates the impact of ofatumumab in Relapsing Remitting Multiple Sclerosis (RRMS) participants that are very early in the course of their disease using clinical and magnetic resonance imaging (MRI) outcomes. The study also assesses changes in disease using monitoring techniques including digital biometric device use, biomarker analysis and non-conventional MRI. Select outcomes in the ofatumumab treated group will be compared to a group of Healthy participants to determine if there are similarities between the groups after the patients with MS undergo treatment with ofatumumab.
Key facts
- Study ID
- NCT05084638
- Run by
- Novartis Pharmaceuticals
- People needed
- 180
- Starts
- 2022-01-25
- Expected to finish
- 2026-02-11
- Last updated by the study team
- 2026-02-27
Who can join
Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.
Where it is running
- MD First Research — Chandler, Arizona, United States
- Barrow Neurological Clinics at St Josephs Hospital and MC — Phoenix, Arizona, United States
- Arizona Neuroscience Research LLC — Phoenix, Arizona, United States
- Keck School of Medicine — Los Angeles, California, United States
- Lundquist Inst BioMed at Harbor — Torrance, California, United States
- Regina Berkovich MD PhD Inc — West Hollywood, California, United States
- UC Health Neuroscience Ctr — Aurora, Colorado, United States
- MedStar Health — Washington D.C., District of Columbia, United States
- Neurology of Central FL Res Ctr — Altamonte Springs, Florida, United States
- First Choice Neurology — Boca Raton, Florida, United States
- University of Florida — Gainesville, Florida, United States
- Neurology Associates PA — Maitland, Florida, United States
- Orlando Health Clinical Trials — Orlando, Florida, United States
- Emerald Coast Neurology — Pensacola, Florida, United States
- Tallahassee Neurological Clinic — Tallahassee, Florida, United States
- University Of South Florida — Tampa, Florida, United States
- Shepherd Center — Atlanta, Georgia, United States
- Ochsner Cancer Institute — New Orleans, Louisiana, United States
- University of Massachusetts Medical School — Worcester, Massachusetts, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- Renown Institute for Neurosciences — Reno, Nevada, United States
- Neuroscience Institute at Hackensack — Hackensack, New Jersey, United States
- University of New Mexico — Albuquerque, New Mexico, United States
- Velocity Clinical Research — Raleigh, North Carolina, United States
- Neurology Diagnostics Inc — Dayton, Ohio, United States
Full record on ClinicalTrials.gov
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