Glucose Homeostasis, Metabolomics and Pregnancy Outcomes After Bariatric Surgery
Recruiting now
Conditions studied: Bariatric Surgery Status Complicating Pregnancy
In brief
The aim of the GLORIA study is to determine whether an altered glucose metabolism (with more hypoglycaemia and glycaemic variability) and altered metabolomics during pregnancy after bariatric surgery contribute to the increased risk for adverse pregnancy outcomes such as small-for-gestational age infants. In addition, the investigators also aim to evaluate whether continuous glucose monitoring (CGM) can be used to diagnose gestational diabetes (GDM).
Key facts
- Study ID
- NCT05084339
- Run by
- Universitaire Ziekenhuizen KU Leuven
- People needed
- 190
- Starts
- 2023-01-25
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-05-05
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Age 18-45 years and with a singleton pregnancy with ultrasound-confirmed gestational age up to 11 weeks and 6 days
- for the group with bariatric surgery: history of gastric bypass (RYBG) or sleeve gastrectomy (SG)
- Participants need to speak and understand Flemish, French or English and have e-mail access.
You may not qualify if…
- multiple pregnancy
- pregnancy ≥12 weeks
- other types of bariatric surgery than RYBG or SG
- known pregestational diabetes
- a physical or psychological disease likely to interfere with the conduct of the study
- medications known to interfere with glucose metabolism.
Where it is running
- OLV-Aalst-Asse — Aalst, Belgium (enrolling)
- UZA — Antwerp, Belgium (enrolling)
- ZNA Antwerpen — Antwerp, Belgium (enrolling)
- Imelda Bonheiden — Bonheiden, Belgium (enrolling)
- AZ St-Jan Brugge — Bruges, Belgium (enrolling)
- UZ Gent — Ghent, Belgium (enrolling)
- AZ Groeninge Kortrijk — Kortrijk, Belgium (enrolling)
- UZ Leuven — Leuven, Belgium (enrolling)
Full record on ClinicalTrials.gov
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