Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients

Completed · Phase 3

Conditions studied: Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury

In brief

Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1. Evaluate PRBC equivalents transfused in each group in the first 24 hours (Primary outcome) 2. Evaluate total transfusion in each group in the first 24 hours (Secondary Outcome) including breakdown by FFP equivalents, platelet units, and cryoprecipitate 3. Evaluate 6 hour, 24 hour, and hospital mortality (Secondary Outcome) 4. Evaluate ICU outcomes in each group

Key facts

Study ID

NCT05081063

Run by

Loma Linda University

People needed

199

Starts

2022-03-05

Expected to finish

2023-05-15

Last updated by the study team

2025-08-08

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• all adult male patients brought into the emergency department as LEVEL A trauma activations who are receiving emergency blood transfusions

You may not qualify if…

• Female patients (specifically excluded due to risk of alloimmunization of Rh-negative female patients of childbearing age against Rh-positive blood)
• children
• prisoners
• all patients classified as dead upon arrival to the trauma bay

Where it is running

• Loma Linda University Health — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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