Biomarker of Diabetic Retinopathy

Recruiting now

Conditions studied: Diabetic Retinopathy

In brief

Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional. This can lead to an improper supply of oxygen and nutrients to the retinal tissue, or it may trigger the formation of new blood vessels in response to the oxygen/nutrient deficiency. Ultimately affecting the normal vision. There is no known marker that will provide information on the health status of retinal blood vessels. Using highly specialized cells in the blood, this study will try to discover a marker of DR.

Key facts

Study ID: NCT05079399
Run by: Indiana University
People needed: 192
Starts: 2022-01-01
Expected to finish: 2027-06-30
Last updated by the study team: 2026-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Ability to cooperate with imaging procedures.
Health status: established type 2 diabetes
No history of panretinal photocoagulation (PRP)
No history of treatment with intravitreal agents for past 12 months

You may not qualify if…

Previous or current malignancy
Acute or chronic infection (HIV, hepatitis B or C, tuberculosis)
Cerebral vascular accident or cerebral vascular procedure
Current pregnancy
History of organ transplantation
Presence of a graft (to avoid any effect of the graft)
History of previous vitrectomy
Subjects with a history of age-related macular degeneration age-related macular degeneration (AMD), glaucoma, uveitis, and branched or central vein occlusion.

Where it is running

Spring Mill Clinic — Carmel, Indiana, United States (enrolling)
Eskenazi Eye Clinic — Indianapolis, Indiana, United States (enrolling)
Glick Eye Institute — Indianapolis, Indiana, United States (enrolling)

Full record on ClinicalTrials.gov

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