Music and Brain Stimulation for Upper Extremity Performance in Patients With Corticobasal Syndrome
Running, not enrolling · Not applicable · Has a placebo group
Conditions studied: Corticobasal Syndrome, Upper Extremity Dysfunction
In brief
This study is designed to investigate how musical patterns (e.g., patterned sensory enhancement, PSE) and non-invasive brain stimulation (e.g., transcranial direct current stimulation, tDCS) are effective to improve functional upper extremity performances in patients with corticobasal syndrome (CBS). 20 individuals with CBS will be randomly assigned to either PSE group (n= 10) or PSE+tDCS (n=10) group. Both interventions are 30 minutes long, twice a week for three weeks (a total of 6 sessions). Participants' self-reported and measurable outcomes including upper extremity function, kinematic quantities, quality of life, mood, cognitive level, and brain activity (e.g. electroencephalography, EEG) will be assessed in the baseline, pre- and post- each session, and follow-up phase. This study seeks to assess the possibility that music-based intervention and non-invasive brain stimulation may improve outcomes in CBS patients for patients' non-invasive but cost-effective rehabilitation settings in the future.
Key facts
- Study ID
- NCT05073471
- Run by
- Johns Hopkins University
- People needed
- 20
- Starts
- 2022-04-22
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-06-08
Who can join
Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with CBS
- Age range 18-89
- Right-handed
You may not qualify if…
- A history of migraines
- Have a scalp or skin condition (e.g., psoriasis or eczema)
- Have any metallic implants, including intracranial electrodes, surgical clips, shrapnel or a pacemaker
- Have had a head injury resulting in a loss of consciousness that has required further investigation
- Have diagnosed psychological or neurological disorders
- Have had a seizure
- Have had adverse effects to previous tDCS or other brain stimulation techniques (e.g., TMS)
- Pregnancy
- Inability or unwillingness to follow directions for study procedures
Where it is running
- Johns Hopkins School of Medicine — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.