Cardiometabolic Effects of Pecans as a Snack
Completed · Phase 2
Conditions studied: Cardiovascular Diseases
In brief
A randomized, 2-arm, parallel trial will be conducted to examine the effect of pecans on markers of peripheral vascular health, lipids and lipoproteins, blood pressure, and glycemic control.
Key facts
- Study ID
- NCT05071807
- Run by
- Penn State University
- People needed
- 138
- Starts
- 2022-08-15
- Expected to finish
- 2024-03-01
- Last updated by the study team
- 2025-02-25
Who can join
Age: 25 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- BMI 25-40 kg/m2
- ≥ 1 criterion for metabolic syndrome (i.e., waist circumference ≥ 94 cm men or ≥ 80 cm women; triglycerides ≥150 mg/dL; HDL-cholesterol ≤ 40 mg/dL men or ≤ 50 mg/dL women; systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg; fasting plasma glucose ≥100 mg/dL) at screening
You may not qualify if…
- Current use of tobacco-containing products or (≤6 months) cessation
- Allergy/sensitivity/intolerance/dislike of study foods
- Women who are pregnant, lactating, planning to become pregnant or have given birth in the past year
- Individuals who have had a cardiovascular event (heart attack, revascularization, stroke), or have a history of heart failure, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis.
- Type 1 or type 2 diabetes
- Unstable weight ≥10% body weight for 6 months prior to enrollment
- Systolic Blood pressure >160 mmHg for systolic pressure and/or diastolic blood pressure >/100 mmHg for diastolic pressure at screening
- Fasting blood glucose ≥126 mg/dL at screening
- Triglycerides ≥350 mg/dL at screening
- Taking any medications known to affect lipids, blood pressure, or blood glucose levels
- Diagnosed inflammatory conditions or taking prescribed , taking any chronic anti-inflammatory medications (>1 time per week over the past 3 months)
- Use of antibiotics within the prior 8 weeks
- Taking supplements (e.g., psyllium, fish oil, soy lecithin, and phytoestrogens) and botanicals known to affect study outcomes and not willing to cease for the duration of the study
- Individuals consuming >14 alcoholic drinks/week, and not willing to avoid alcohol consumption for 48 hours prior to test visit
- Pre-menopausal women who do not have a regular menstrual cycle of 25-35 days
- PI discretion
Where it is running
- Penn State University — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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